Juhib: Marge Kusmin Murilo Matos Mendonca Santa Catarina Virtual University On overview of the scenario of e-learning in distance education in Brazil shall be provided to set the scene. Then, the case of UnisulVirtual, the virtual campus of Unisul (University of Southern Santa Catarina) will be presented with the systems used by UnisulVirtual, its VLE, methodology, production processes, challenges faced to deliver e-learning in a country of continental dimensions and great socio-cultural diversity. Finally, the international collaboration projects in which UnisulVirtual participate will be shown